Mitochondrial P-450 activities in aldosteronoma tissues

Abstract Adrenal P -450 activities were measured by an in vitro reconstitution system from tissues obtained from human aldosteronomata, and the results compared with those of the normal adrenal tissues from patients with Grawitz's tumor. The P -450 11 β activity was significantly increased in adenoma tissue (55.6 ± 5.3 vs 9.0 ± 6.2 nmol corticosterone/mg of protein/min in the control tissues, P P -450 scc activity in adrenal adenomata was 13.4 ± 2.0 nmol pregnenolone/mg of protein/min, significantly higher than control ( P P -450 11 β activities may be characteristic of aldosterone-producing adenomata.