Gene expression profile of dermal mesenchymal stem cells from patients with psoriasis.

Background Mesenchymal stem cells (MSCs) are likely involved in pathological processes of immune-related diseases, including psoriasis because of their immunoregulatory and pro-angiogenic effects, and the vascular proliferation, angiectasis and perivascular lymphocyte infiltration are known to be predominantly responsible for the pathological alterations in psoriasis. Objective This study aimed to investigate the gene expression profile of dermal MSCs from patients with psoriasis. Methods We isolated and expanded dermal MSCs from psoriatic patients and normal controls by using the attachment assay and conducted mRNA expression profile and gene ontology analyses using microarray. Results The gene expression profile of MSCs from psoriatic derma was markedly different from the normal derma-derived MSCs; the angiogenesis-related genes such as vascular endothelial growth factor A, insulin-like growth factor-binding protein-5, and GATA6 showed significant differential expression. Conclusions These results indicate that MSCs from the derma of psoriasis patients might be involved in the early development of psoriasis because of their pro-angiogenic potential as well as the immunoregulatory effect.