TAG-1–assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding
2013
The authors show that shortening of the basal process in neural progenitor cells by depletion of TAG-1 results in overcrowding in the periventricular space and, eventually, delamination and aberrant migration. These results suggest that one of the functions of interkinetic nuclear migration is to prevent progenitor congestion and mechanical stress.
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