Therapeutic effect study of bushen huoxue formula on the experimental model of alzheimer's disease

Objective To observe the therapeutic effect of Bushen huoxue formula to experimental animal model of Alzheimer's disease.Methods established AD animal model with Aβ25-35 encephalic injection once and D-galactose hypodermical injection for 5 weeks,then administrated the rats with drugs for 4 weeks,after that,check the cognitive behavior with Morris mater maze experiment,and survey the contents of SOD and MDA of the brains.Results After administrated the animal with Bushen huoxue formula,the searching time and distance in safety island quadrant were lengthened.The formula also diminished the content of MDA and elevated the activity of SOD.Conclusion Bushen huoxue formula obviously improved the learning and memonic capacity of AD rats,its mechanism may has certain relationship to its regulating lipid peroxidation reaction effect.