Pyridoxine hydroxamic acids as novel HIV-integrase inhibitors.

Brent Richard Stranix,Jinzi J. Wu,Guy Milot,Francis Beaulieu,Jean-Emanuel Bouchard,Kristine Gouveia,André J. Forté,Seema Garde,Zhigang Wang,Jean Francois Mouscadet,Olivier Delelis,Yong Xiao

Pyridoxine hydroxamic acids as novel HIV-integrase inhibitors.

2016

Brent Richard Stranix
Jinzi J. Wu
Guy Milot
Francis Beaulieu
Jean-Emanuel Bouchard
Kristine Gouveia
André J. Forté
Seema Garde
Zhigang Wang
Jean Francois Mouscadet
Olivier Delelis
Yong Xiao

A series of pyridoxine hydroxamic acid analog bearing a 5-aryl-spacers were synthesized. Evaluation of these novel HIV integrase complex inhibitors revealed compounds with high potency against wild-type HIV virus.

Keywords:

Biochemistry
Viral replication
Virus
Structure–activity relationship
Potency
Chemistry
Integrase
HIV Integrase Inhibitors
Virology
Pyridoxine
Hydroxamic acid

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