Single-nucleus RNA sequencing reveals transcriptional changes of hippocampal neurons in APP23 mouse model of Alzheimer’s disease

Shan Zhong,Mengdi Wang,Yaxi Zhan,Jie Zhang,Xiaoli Yang,Shumei Fu,Danlei Bi,Feng Gao,Yong Shen,Zuolong Chen

Single-nucleus RNA sequencing reveals transcriptional changes of hippocampal neurons in APP23 mouse model of Alzheimer’s disease

2020

Shan Zhong
Mengdi Wang
Yaxi Zhan
Jie Zhang
Xiaoli Yang
Shumei Fu
Danlei Bi
Feng Gao
Yong Shen
Zuolong Chen

ABSTRACTAlzheimer’s disease (AD) is a progressive neurodegenerative disorder that mostly strikes the elderly. However, the exact molecular and cellular pathogenesis of AD, especially the dynamic ch...

Keywords:

Disease
Nucleus
RNA
Pathogenesis
Biology
Molecular biology
Hippocampal formation
Neuroscience
Progressive neurodegenerative disorder

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