Decline of varicella vaccination in German surveillance regions after recommendation of separate first-dose vaccination for varicella and measles–mumps–rubella

Abstract Background Germany introduced routine varicella (V) vaccination in 2004. Due to a slightly increased risk of febrile convulsions after first-dose application of combined measles–mumps–rubella–varicella (MMRV) vaccine separate first-dose vaccinations with MMR and monovalent V vaccine were recommended in September 2011. Methods We compared V and MMR vaccinations in paediatric practices from two surveillance regions (Munich and Wurzburg) one year before and after the change in the recommendation. Results A total of 1405/326 monthly reports were provided by a monthly average of 79/14 practices participating in Munich/Wurzburg. V first-dose vaccinations (monovalent V or MMRV vaccine) declined by 12% in Munich (from 10.1 to 8.9 vaccinations per month and practice; p p  = 0.620), respectively. First-dose vaccinations for MMR (MMR or MMRV vaccine) did not change significantly in both regions. Conclusion Acceptance of V vaccination depends in part on the use of combination vaccine.