Polyacetylenes and flavonoids from the stems and leaves of Pyrethrum tatsienense

Abstract One previously undescribed polyacetylene, erythro-(5E)-1,5-didecadiene-7,911-triyne-3,4-diacetate (1), two previously undescribed flavonoids named tricin-7-O-ethylglucuronide (2) and tricin 4′-O-(erythro-β -guaiacylglyceryl) ether 5-O-β-glucopyranoside (3), together with four known polyacetylenes (4-7) and fourteen known flavonoids (8-21) were isolated from alcoholic extracts of the stems and leaves of Pyrethrum tatsienense (SLPT). Their structures were elucidated by extensive analysis of NMR and mass spectroscopic data as well as chemical reactions. Among all isolates, polyacetylenes were found as a new structural type from P. tatsienense for the first time. Tricin and its derivatives were common compositions between SLPT and the flowers of P. tatsienense (FPT). According to previous reports, tricin and its derivatives are responsible for the anti-inflammatory activity of FPT. These findings suggested that SLPT might be worthy of further development and research as medicinal parts.