Imide-based proteolytic modulators and related methods of use

The present invention relates to imide-based compounds and bifunctional compounds containing them, which compounds are degraded and / or otherwise inhibited by the bifunctional compounds according to the invention, in particular as modulators of targeted ubiquitination. It is useful as an inhibitor for various polypeptides and other proteins. Specifically, the present invention provides a ligand that binds cereblon E3 ubiquitin ligase at one end so that the target protein is placed in close proximity to the ubiquitin ligase resulting in degradation (and inhibition) of the protein, The compound containing the part couple | bonded with a target protein is provided at the terminal. Compounds can be synthesized that exhibit a wide range of pharmacological activities consistent with degradation / inhibition of almost any type of target polypeptide.