Tissue changes in the intervertebral disk following hypokinesia in rats of different ages

Effect of various duration of hypokinesia on structural-metabolic characteristics of the lumbar vertebral segment has been studied in Wistar rats. Hypokinesia results in certain morphological changes of the spongy bone and tissues of the intervertebral disk, demonstrating as delayed processes of ossification, disturbed course of organization into bundles of collagenous fibers of the fibrous ring, widening of the nucleus pulposus zone. Polarization-optical investigations reveal some disturbances in the macro-molecular organization of collagen, expressed as decreasing degree of its refraction and as redistribution of glycosaminoglycans towards increasing sulfated keratan sulfates.