コントロール不良な日本人重症喘息患者を対象とした主観的負荷に関するインターネット調査―SHIRAHAE study―

Background：Severe, uncontrolled asthma is associated with increased exacerbations, use of oral corticosteroids, and frequent hospitalizations. Few studies have examined the patient‒reported subjective burden of severe, uncontrolled asthma. Object：To evaluate the type and extent of the subjective burden of severe, uncontrolled asthma in Japanese patients, and descriptively compare their perceptions with those of patients with severe, controlled asthma. Method：SHIRAHAE was a non‒inter ventional, internet sur vey of Japanese patients（aged≧20 years）with a diagnosis of asthma, who were on continuous treatment with an inhaled corticosteroid（ICS）or ICS/long‒acting β2 agonist. Patients completed a 42‒item questionnaire on the subjective burden of asthma. Asthma control status and patient satisfaction with current asthma treatment were separately evaluated. Results：Among 3272 enrolled patients, 698 patients had severe asthma, which included 499 with uncontrolled asthma and 199 with controlled asthma. Greater percentages of patients with severe, uncontrolled asthma selected“extremely applicable”or “applicable”for all questions as compared with patients with severe, controlled asthma, indicating a greater subjective burden of severe, uncontrolled asthma. Although asthma control status was not well controlled in whole patients population, approximately 60％ of whole patients were satisfied with their current asthma treatment. Conclusion：This study showed that patients with severe, uncontrolled asthma had a greater subjective burden of asthma compared with patients with controlled asthma or non‒severe asthma.