Solubility Enhancement of Clarithromycin

The solubility enhancement is essential key factor to rise Bioavailability as well as Dissolutionrate of a drug. In solvent the dissolution phenomenon of solute is to provide a homogenoussystem that means solubility is an essential key factor to attain desired drug’s concentration forideal pharmacological effect. The rise in solubility plays an important part for absorption ofmedication that specifically help to raise the healing consequence of that particular medication.H pylori areBacteria which lead to peptic ulcer. The complete eradication of h pylori is achallenging aspect so generally combination therapy is employed in which Antibacterial alongwith PPI and for inhibition of growth of bacteria generally bacteriostatic is used.Clarithromycin is used as Antibacterial agent having the bactericidal property. The Solubilityof this drug was increased by preparing the solid dispersions by solvent evaporation approachhaving various ratio of 2 different polymers PEG 6000 along with PEG 4000.