Synthesis, Crystal Structures, Fluorescence and Xanthine Oxidase Inhibitory of Sulfur-Containing Pyrazole Derivatives Incorporated with Oxadiazole and Triazole

Some sulfur-containing pyrazole derivatives incorporated with 1,3,4-oxadiazole and 1,2,4-triazole were designed and synthesized. All the compounds were fully characterized by IR, 1 H NMR, 13 C NMR and elemental analyses. Two crystal structures were determined by single crystal X-ray diffraction analyses. The fluorescence properties were investigated in DMSO solution. In addition, the in vitro xanthine oxidase (XO) inhibitory activity were evaluated, and the results showed that one compound displayed moderate XO inhibitory activity.