Carboxamide compounds, and amine sulfonamide for metabolic disorders

A compound having the structural formula Formula ** ** or a pharmaceutically acceptable salt, solvate, hydrate or N-oxide thereof, wherein "B" represents - (aryl or heteroaryl) - substituted with R3 w R14 yk; E is -C (O) -, -S (O) 2- or a single bond, with the proviso that when "B" is phenyl, E is not -C (O) -; R1 is H, - (C1-C4) or -C (O) O- (C1-C4); Q and G are each independently a bond, -CH2-, -C (H) (R16) -, -C (R16) 2- or -S (O) 2-; v is 0, 1, 2, 3 or 4; each R15 are independently selected - (C1-C6), - (C1-C6), - (alkyl C0-C6) -L-R7, - (alkyl C0-C6) -NR8R9, - (alkyl C0 C6) -OR10, - (C0-C3 alkyl) -C (O) R10, - (C0-C6 alkyl) -S (O) 0-2R10, -halogen, -NO2 and - CN, and two R15 on the same carbon optionally combine to form oxo; R17 is aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents independently selected from - (C1-C6), - (C1-C6), - (alkyl C0-C6) -L-R7, - (alkyl C0-C6) -NR8R9, - (C0-C6 alkyl) -OR10, - (C0-C6 alkyl) -C (O) R10, - (C0-C6 alkyl) -S (O) 0-2R10, -halogen, -NO2 and -CN; each R3 is substituted on benzo carbon or pyrido ring system represented by "B" and are independently selected - (C1-C6), - (C1-C6), - (alkyl C0-C6) -L -R7, - (C0-C6 alkyl) -NR8R9, - (C0-C6 alkyl) -OR10, - (C0-C6 alkyl) -C (O) R10, - (C0-C6 alkyl) -S (O) 0 -2R10, -halogen, -NO2 and -CN; w is 0, 1, 2 or 3; each R14 is substituted on a carbon not-benzo, non-pyrido ring system represented by "B" and is independently selected from (C1-C6), - (C1-C6), - (alkyl C0-C6 ) -Ar, - (C0-C6 alkyl) -Het, - (C0-C6 alkyl) -Cak, - (C0-C6 alkyl) -Hca, - (C0-C6 alkyl) -L-R7, - (alkyl C0 C6 alkyl) -NR8R9, - (C0-C6 alkyl) -OR10, - (C0-C6 alkyl) -C (O) R10, - (C0-C6 alkyl) -S (O) 0-2R10, -halogen, - NO2 and CN; k is 0, 1 or 2; each R4 is independently selected from selected - (C1-C6), - (C1-C6), - (alkyl C0-C6) -L-R7, - (alkyl C0-C6) -NR8R9, - (alkyl C0 C6) -OR10, - (C0-C6 alkyl) -C (O) R10, - (C0-C6 alkyl) -S (O) 0-2R10, -halogen, -NO2 and - CN and two R4 on the same carbon optionally combine to form oxo; x is 0, 1, 2, 3 or 4; the ring system represented by "A" is phenyl or monocyclic heteroaryl; each R5 are independently selected - (C1-C6), - (C1-C6), - (alkyl C0-C6) -L-R7, - (alkyl C0-C6) -NR8R9, - (alkyl C0 C6) -OR10, - (C0-C6 alkyl) -C (O) R10, - (C0-C6 alkyl) -S (O) 0-2R10, -C (O) -Hca, - halogen, -NO2 and - CN; y is 0, 1, 2, 3 or 4; wherein each L is independently selected from -NR9C (O) O-, -OC (O) NR9-, -NR9C (O) -NR 9, -NR 9 C (O) S-, - SC (O) NR9- , -NR9C (O) -, -C (O) -NR 9, -NR 9 C (S) O-, -OC (S) NR9-, -NR9C (S) -NR 9, -NR 9 C (S) -S-, -SC (S) NR9-, -NR9C (S) -, -C (S) NR9-, -SC (O) NR9-, -NR9C (S) -, -S (O) 0-2-, -C (O) O, -OC (O) -, -C (S) O-, -OC (S) -, -C (O) S-, -SC (O) -, -C (S) S-, -SC (S) -, -OC (O) O-, -SC (O) O-, -OC (O) S-, -SC (S) O-, -OC (S) S-, -NR9C ( NR2) NR9-, -NR9SO2-, -SO2NR9- and -NR9SO2NR9-, each R7, R8 and R10 are independently H, selected - (C1-C6), - (C1-C6), - (alkyl C0 - C6) -L- (alkyl C0-C6), - (alkyl C0-C6) -NR 9 (alkyl C0-C6), - (alkyl C0-C6) -O- (C0-C6 alkyl), - (alkyl C0 C6) -C (O) - (C0-C6 alkyl) and - (C0-C6 alkyl) -S (O) 0-2- (C0-C6 alkyl), each R9 is independently selected from -H, - (C1-C4) and -C (O) O- (C1-C4), each R16 is independently selected from - (C1-C6), - (C1-C6), - (C0-C6 alkyl ) -L-R7, - (C0-C6 alkyl) -NR8R9, - (C0-C6 alkyl) -OR10, - (alk as C0-C6) -C (O) R10, - (C0-C6 alkyl) -S (O) 0-2R10, -halogen, -NO2 and - CN, and optionally two R16 on the same carbon combine to form a oxo, each Ar is an optionally substituted aryl, each Het is an optionally substituted heteroaryl, each Cak is an optionally substituted cycloalkyl, each Hca is an optionally substituted heterocycloalkyl, and each alkyl is optionally substituted, where the optional substituents of atoms saturated carbon are selected from -R60, halo, -OM +,> = O, -OR70, -SR70, -S-M +,> = S, -NR80R80,> = NR70,> = N-OR70, trihalomethyl, - CF3, -CN, -OCN, -SCN, -NO, -NO2,> = N2, - N3, -SO2R70, -SO2O-M +, -SO2OR70, -OSO2R70, -OSO2O-M +, -OSO2OR70, -P (O ) (O-) 2 (M +) 2, -P (O) (OR70) O-M +, - P (O) (OR70) 2, -C (O) R70, -C (S) R70, -C ( NR70) R70, -C (O) O-M +, -C (O) OR70, -C (S) OR70, -C (O) NR80R80, -C (NR70) NR80R80, - OC (O) R70, -OC (S) R70, -OC (O) O-M +, -OC (O) OR70, -OC (S) OR70, -NR70C (O) R70, -NR70C (S) R70, -NR70CO2 -M +, - NR70CO2R70, -NR70C (S) OR70, -NR70C (O) NR80R80 , -NR70C (NR70) R70 and -NR70C (NR70) NR80R80; the optional substituents on the unsaturated carbon atoms are selected from -R60, halo, -O-M +, -OR70, -SR70, -S-M +, -NR80R80, trihalomethyl, -CF3, -CN, -OCN, -SCN , -NO, -NO2, -N3, -SO2R70, -SO3 -M +, -SO3R70, -OSO2R70, -OSO 3 -M +, -OSO3R70, -PO3 -2 (M +) 2, -P (O) (OR70) O -M +, -P (O) (OR70) 2, -C (O) R70, -C (S) R70, -C (NR70) R70, -CO2 -M +, - CO2R70, -C (S) OR70, - C (O) NR80R80, -C (NR70) NR80R80, -OC (O) R70, -OC (S) R70, -OCO2 -M +, -OCO2R70, -OC (S) OR70, - NR70C (O) R70, - NR70C (S) R70, -NR70CO2 -M +, -NR70CO2R70, -NR70C (S) OR 70, -NR70C (O) NR80R80, -NR70C (NR70) R70 and - NR70C (NR70) NR80R80; and optional substituents on the nitrogen atoms are selected from -R60, -O-M +, -OR70, -SR70, -S-M +, - NR80R80, trihalomethyl, -CF3, -CN, -NO, -NO2, - S (O) 2R70, -S (O) 2O-M +, -S (O) 2OR70, -OS (O) 2R70, -OS (O) 2O-M +, - OS (O) 2OR70, -P (O) (O-) 2 (M +) 2, -P (O) (OR70) O-M +, -P (O) (OR70) (OR70), -C (O) R70, -C (S) R70, -C (NR70) R70, -C (O) OR70, - C (S) OR70, -C (O) NR80R80, -C (NR70) NR80R80, -OC (O) R70, -OC (S) R70, -OC ( O) OR70, -OC (S) OR70, -NR70C (O) R70, - NR70C (S) R70, -NR70C (O) OR70, -NR70C (S) OR70, -NR70C (O) NR80R80, -NR70C (NR70 ) R70 and -NR70C (NR70) NR80R80, wherein each R60 is H, alkyl or heteroalkyl each R70 is H, alkyl or heteroalkyl each R80 is H, alkyl or heteroalkyl, or alternatively, two R80, taken together with the atom nitrogen to which they are attached form a 5-, 6 or 7 members which may optionally include 1 to 4 of the same or different additional heteroatoms selected from the group consisting of O, N and S, of which N you may have -H or one C1-C3 alkyl substitution. each M + is a counterion with one net positive charge.