Blood pressure variation of hypertensive diabetic nephropathy patients undergoing peritoneal dialysis

Objective To investigate the variance of blood pressure of hypertensive diabetic patients undergoing continuous ambulatory peritoneal dialysis(CAPD).Methods Twenty hypertensive CAPD patients older than 40 years with diabetic nephropathy(DN-PD group) and twenty patients with chronic glomerular nephritis(CGN-PD group) were recruited.Peritoneal status and dialysis adequacy of the patients in the two groups were calculated using PD Adequest.All patients were given 24-hour ambulatory blood pressure monitoring(ABPM).Parameters of blood pressure variation were calculated and compared between the two groups,which included 24 h systolic and diastolic blood pressure variability(24 h SBPV/DBPV) and coefficient of variation(24 h SBPCV/24 h DBPCV),daytime systolic and diastolic blood pressure variability(dSBPV/ DBPV) and coefficient of variation(dSBPCV/dDBPCV),and night time systolic and diastolic blood pressure variability(nSBPV/ DBPV) and coefficient of variation(nSBPCV/nDBPCV).Results No significant differences in clinical characteristics were found between the two groups of patients,except for fast glucose.No significant differences in average systolic and diastolic blood pressures,average pulse pressure and mean 24 h,daytime,and nighttime arterial pressures were found between the two groups.However,the DN-PD group had significantly higher 24 h SBPV,24 h SBPCV,dSBPV and dSBPCV than the CGN-PD group(P0.05).Conclusion Hypertensive diabetic nephropathy patients undergoing peritoneal dialysis have greater blood pressure variance than those with hypertensive chronic glomerular nephritis,despite a similar result of blood pressure control.