Cisplatin and Fluorouracil Alternating Intraperitoneal Perfusion and ECF in Treatment of Primary Peritoneal Carcinoma

Objective To observe the ascites control effects and short-term clinical efficacy and toxicity in the treatment of primary peritoneal carcinoma with cisplatin (DDP),fluorouracil (5-Fu) alternating abdominal perfusion and systemic chemotherapy of ECF (epirubicin,cisplatin,5-fluorouracil).Methods DDP,5-Fu alternating intraperitoneal perfusion plus ECF program intravenous chemotherapy,one cycle of 21 days for a total of 6~8 cycles,was evaluate at least after 4 cycles.Results In 15 cases,the ascites control rate was 86.6%,and the total effective rate (RR) 86.6%,including complete remission (CR) (26.6%),and partial remission (PR) (60%). The major toxicity was Ⅱ~Ⅲ myelosuppression.Conclusion DDP and 5-Fu alternating intraperitoneal perfusion plus ECF in the treatment of primary peritoneal carcinoma has better control of ascites and satisfactory short-term efficacy,slight toxicity light and low-cost. It can be used as first-line treatment programs for primary peritioneal carcinoma.