Experimental study of radioprotective effects of rhIL-8 on irradiated mice and its mechanism

Objective\ To study the radioprotective effects of rhIL\|8 on irradiated mice and its mechanism. Methods\ Single intraperitoneal injections of rhIL\|8 at 10 μg or 30 μg at different times to BALB/c mice before they were exposed to 8.5 Gy or 6.5 Gy 6 MV X\|rays.The survival state of mice and some monitoring indices were observed. Results\ The survival times of irradiated mice were closely related to the dose lever of rhIL\|8 and the injection time.CFU\|GM counts of bone marrow cells,serum total contents of superoxide dismutase (T\|SOD) and malondialdehyde (MDA),and immunity function indices were examined in all mice at six days after expousure 6.5 Gy 6 MV X\|rays.It is showed that the examination findings and the survival state of irradiated mice were interrelated with one another. Conclusion\ rhIL\|8 has certain radioprotective effects through complex mechanisms of modulation of hematopoiesis, immuno\|modulation,clearance of free radicals,etc.\;