Stress and reproductive disorders: modern views on the problem and own research experience

Modern therapy of infertility in men is mainly associated with the use of hormonal and anti-hormonal drugs, but hormonal therapy often leads to a number of negative complications. The list of non-hormonal nature is extremely limited, which is why the study of effective and safe non-hormonal drugs for the treatment of pathospermia and infertility remains an urgent task. The purpose of our work was to evaluate the effectiveness of the new biologically active compound Katiazin — a non-hormonal medicine — for the treatment of pathospermia. The work was performed on sexually mature 6-month rats’ males of the Vistar population. To simulate the pathology of spermatogenesis, animals were stressed for seven days by daily one-hour immobilization on the back with fixation of both pairs of paws. The appointment of Katiazin was carried out from the first day of male exertion in a dose of 0.6 mg/kg body weight daily for 21 days intragastrically. Generative function of males was estimated by the indicators of spermogram and morphometric analysis of the histological structure of the testicles. It was founf that stressing of rats affects all the indicators of spermatogenesis, namely, the amount and mobility of spermatozoa decreases and, conversely, the percentage of pathological cells increases. In animals who taking the Katiazin, all the parameters of spermogram of rats were improved. The analysis of morphometric data suggests that the formation of germ cells at the stage of maturation of sperm from the spermatoid and the stage of spermatogenesis is activated under the influence of Katiazin. The results allow us to recommend Katiazin for the development of a new drug for the treatment of male infertility.