Changes in casein component‐specific antibody levels during oral immunotherapy for milk allergy

: Casein (CN) is the major cow's milk (CM) allergen in patients with CM allergy (CMA).1 Bovine CN consists of four fractions, αs1-, αs2-, β-, and κ-CNs. Oral immunotherapy (OIT) is a recommended clinical procedure2 and its curative effect and induced changes in the immune response are promising.3-5 Studies on CM-OIT have reported decrease of specific IgE (sIgE) and increase of specific IgG4 (sIgG4) levels to CM proteins, CN, or whey proteins.6,7 However, only few studies have focused on CN component-specific antibodies during CM-OIT. Herein, we evaluated changes in purified CN component-specific antibodies during CM-OIT and then compared the results with clinical outcomes.