[Comparative clinical study between standard hemodialysis, PHF (HDF on-line) and PHF AF (HDF on-line acetate free)].

PURPOSE AND METHODS: In this study, three different techniques were compared in eight uremic patients on regular dialysis treatment: standard hemodialysis (HD), paired hemodiafiltration (PHF) and PHF acetate free (AF). We evaluated the Kt/V, the percentage reduction in Beta 2-microglobulin, the acid-base balance (blood samples were drawn pre-treatment and after 30, 60, 120 and 180 min, post-treatment and pre-treatment of the following session) and the acetate plasma concentration pre- and post-treatment. RESULTS: Between these treatments there were no significant differences in Kt/V and in urea reduction rate (URR). The percentage reduction in plasma Beta 2-microglobulin levels was significantly higher in PHF and in PHF AF than in standard HD. CONCLUSIONS: The correction of acidosis was not significantly different between standard HD and PHF, while it was significantly less effective in PHF AF. The post-dialysis plasma acetate concentration was significantly lower in PHF AF than in standard HD and in PHF with an improvement in cardiovascular (CV) stability and a reduction in oxidative stress.