The association of serum uric acid with metabolic syndrome and its components-- from a single clinical center in China.

BACKGROUND AND OBJECTIVES Increasing evidence suggests that uric acid (UA) levels may play a role in the MetS. The purpose of this study was to the association of serum uric acid with metabolic syndrome and its components from a single clinical center in China. SUBJECTS AND METHODS We retrospectively analyzed the physical examination information of patients at the Health Checkup Center of the Beijing Friendship Hospital, Capital Medical University in 2018. MetS was defined as ≥3 of the risk factors according to the revised Harmonized criteria. Statistical analyses were performed using the SPSS statistical software package, version 22.0 (IBM Corporation, Armonk, NY, USA). RESULTS A total of 36663 subjects were retrospectively analyzed. The incidence of MetS was 23.6% among the study participants and 38.9% in subjects with HUA. The incidence of HUA was 33.3% in the MetS group. Higher SUA levels were correlated with an increased risk of having full MetS, hypertriglyceridemia and low HDL-C after adjustment (all P<0.001 for the trend). Only in males were higher SUA levels correlated with an increased risk of being overweight. Individuals with the highest quartile of SUA had no significant association with having HP in males, and a significant association between SUA levels and hypertension was only seen in the highest quartile of females. Males with the highest quartile of SUA (Q4) and females with the higher quartiles of SUA (Q3 and Q4) had no significant association with having hyperglycemia. CONCLUSION The incidence of HUA was increased in the MetS group consisting of Chinese patient subjects living in Beijing. SUA is strongly associated with full MetS as well as hypertriglyceridemia and low HDL-C. The relationship between HUA and an overweight BMI, HP and hyperglycemia varied by gender.