SYNTHESIS, IDENTIFICATION AND DETERMINATION OF IMPURITIES IN BIOACTIVE HYDROXYAPATITE

A method for the synthesis of bioactive hydroxyapatite (HA) adapted for industrial production is described. It is established that a nanocrystalline HA gel more effectively stimulates osteogenic activity than does HA powder. In addition, the HA gel is suitable as injection for direct introduction into bone wounds and can be used for the impregnation of porous ceramic implants in order to improve their bioactivity and biocompatibility. It is shown that thermal and gamma-ray sterilization of HA-based preparations does not influence their properties as well as their stability during 3-year storage.