Free amino acid spectrum and cathepsin activity in the blood serum of patients with diabetes mellitus combined with diffuse toxic goiter

Clinicobiochemical studies were performed to determine the spectrum of free aminoacids and cathepsin activity in the blood serum of 96 patients with the moderate stage of diabetes mellitus, diffuse toxic goiter, accompanied by normo- or hyperglycemia and in combined pathology: diabetes mellitus and diffuse toxic goiter. Pronounced hyperaminoacidemia in moderate diabetes mellitus, moderate hyperaminoacidemia in diffuse toxic goiter with normo- or hyperglycemia and increased cathepsin activity were revealed. In combined pathology mild thyroid hyperfunction diminished hyperaminoacidemia and cathepsin activity in patient with diabetes mellitus, apparently rendering a positive effect on protein-aminoacid metabolism.