Expression of Regeneration-Associated Proteins in PrimarySensory Neurons and Regenerating Axons After Nerve Injury-AnOverview
2018
Peripheral nerve injury results in profound alterations of the
affected neurons resulting from the interplay between intrinsic
and extrinsic molecular events. Restarting the neuronal
regenerative program is an important prerequisite for
functional recovery of the injured peripheral nerve. The
primary sensory neurons with their cell bodies in the dorsal
root ganglia provide a useful in vivo and in vitro model for
studying the mechanisms that regulate intrinsic neuronal
regeneration capacity following axotomy. These studies
frequently need to indicate the regenerative status of the
corresponding neurons. We summarize the critical issues
regarding immunohistochemical detection of several
regeneration-associated proteins as markers for the initiation
of the regeneration program in rat primary sensory neurons and
indicators of axon regeneration in the peripheral nerves. This
overview also includes our own results of GAP43 and SCG10
expression in different DRG neurons following double
immunostaining with molecular markers of neuronal
subpopulations (NF200, CGRP, and IB4) as well as transcription
factors (ATF3 and activated STAT3) following unilateral sciatic
nerve injury. Anat Rec, 301:1618-1627, 2018. (c) 2018 Wiley
Periodicals, Inc.
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