The cortical vibrissae representation is normal in transgenic mice lacking the 5-HT1B receptor

Abstract Recent studies have suggested that 5-HT may modulate thalamocortical development in somatosensory cortex (S-I) of rats and mice, and that the 5-HT 1B receptor may play a critical role in this process. Analysis of CO-stained sections through lamina IV of S-I in perinatal and adult 5-HT 1B knockout mice revealed a normal vibrissae-related pattern, indicating that activation of the 5-HT 1B receptor is not necessary for the normal development of the vibrissae representation in S-I.