Biphenyl and heteroaryl phenyl derivatives as protein tyrosine phosphatases inhibitors

Disclosed are compounds and pharmaceutically acceptable salts of formula (I) : wherein A, B, D, L1 L2, R2, RA, RB, X, m, n, and p are as defined herein, which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.