Expression of PDGF, PDGF-Receptor, EGF-Receptor and sex hormone receptors on meningioma

The expression of platelet derived growth factors (PDGF), the PDGF-Receptor (R) (α and Β types), epidermal growth factor (EGF)-Receptor (R) and sex hormone (oestrogen and progesterone) receptors was studied in 22 meningiomas. All tumours were PDGF-R Β type positive and 21 (95%) were PDGF positive. Only 2 (9%) were PDGF-R α type positive, 13 (59%) were EGF-R positive. The expression of these proteins was not related to the histological type or the malignancy of the meningiomas although the expression of PDGF and PDGF-R Β tended to be stronger in malignant meningiomas.