Phloeodictines A and B: new antibacterial and cytotoxic bicyclic amidinium salts from the new caledonian sponge, Phloeodictyon sp

Two new alkaloids, phloeodictine A (1) and phloeodictine B (2), possessing an unprecedented 6-hydrory-1,2,3,4-tetrahydropyrrolo [1,2-a]pyrimidinium skeleton have been isolated from an undescribed species of the deep sponge Phleodictyon. The structures mere determined by extensive spectrospic analysis particularly two-dimensional NMR experiments. Both compounds exhibited in vitro antibacterial activity against Gram-positive and Gram-negative bacteria and mere moderately cytoxic against KB cells