Concise and Enantioselective Total Synthesis of 15-Deoxy-Δ12,14-Prostaglandin J2
2010
The concise and enantioselective synthesis of 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) has been accomplished in 11 steps from a known alcohol. The key step of the synthesis involves an asymmetric Rh-catalyzed cycloisomerization of ene-ynone, followed by an olefin isomerization.
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