Lyophilized tablet prepared from warfarin composition and preparation method thereof

2014 
The invention provides a lyophilized tablet prepared from a warfarin composition and a preparation method thereof and belongs to the technical of medicines and medicine production. The lyophilized tablet is prepared from warfarin, starch and sucrose, wherein the starch and the sucrose serve as adjuvants. By heating the common corn starch, the binding and disintegrating effects of the starch in the lyophilized tablet can be improved, and the formability of the lyophilized tablet can be improved. The adjuvants for preparing the lyophilized tablet only comprise the starch and the sucrose. The lyophilized tablet is prepared by decreasing temperature twice and increasing temperature twice, and the twice temperature decrease and twice temperature increase can ensure that the lyophilized tablet can be well formed, the dissolution rate of the lyophilized tablet can be increased and the bioavailability of the lyophilized tablet can be improved. The lyophilized tablet overcomes the defects of the ordinary tablet prepared from warfarin, is prepared by adopting a few kinds of and a small amount of adjuvants compared with the tablet prepared from warfarin, has high dissolution rate and high bioavailability, has a good clinical treatment effect and can be used for clinical treatment safely.
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