Human menstrual blood-derived stem cells as immunoregulatory therapy in COVID-19: A case report and review of the literature

BACKGROUND The coronavirus disease 2019 (COVID-19) caused by novel coronavirus 2019 in December 2019 has spread all around the globe and has caused a pandemic There is still no current effective guidance on the clinical management of COVID-19 Mesenchymal stem cell therapy has been shown to be one of the therapeutic approaches to alleviate pneumonia and symptoms through their immunomo-dulatory effect in COVID-19 patients CASE SUMMARY We describe the first confirmed case of COVID-19 in Hangzhou to explore the role of human menstrual blood-derived stem cells (MenSCs) in the treatment of COVID-19 Moreover, we review the immunomodulation effect including nonspecific and specific immune functions of MenSCs for the therapy of COVID-19 CONCLUSION MenSCs can be helpful to find a promising therapeutic approach for COVID-19 © The Author(s) 2021 Published by Baishideng Publishing Group Inc All rights reserved