血友病患者 (とくに抗HIV抗体陽転のAC, ARCとAIDS) における抗HIV抗体およびHIV抗原の経時的検索とその臨床的有用性

We tested for the anti HIV antibody and the HIV antigen in the sera of 81 hemophiliacs (A 68 cases, B 13 cases), who have been under treatment in our department.The anti HIV antibody was found to be present in 44.3% of the cases, including 7 cases who later changed to positive, and 6 with HIV antigen. In the sera of those 7 seroconverted cases, although the HIV antigen was negative, the p24 antibody was detected by the Western blotting method and the gp41 antibody was detected by the Confirmatory EIA (ENVACORE, Abbott Lab., USA) earlier than by the immunofluorescence method and conventional ELISA. Moreover, in 4 cases who later developed AIDS, HIV turned out positive concurrently with or shortly after the enfeeblement and/or disappearance of the p24 antibody which was associated with a progressive decrease in the CD4/8 ratio of lymphocytes and the development of recurrent oppotunistic infections.Based on these results, it is suggested that the periodical examination for anti p24 and gp41 antibodies and HIV itself might be clinically useful for predicting the development of AIDS and thustreating them at an early stage.