Inhibition of the Mitochondrial ATPase by Polyborate Anions Designed for Neutron Capture Therapy

Mercapto undecahydro dodecaboron designed for neutron capture therapy and several new carboranes showed inhibitory effects on mitochondrial ATPase activity. For mercapto and chloroderivates of carboranes 50% inhibition of ATPase activity was found at 100–200 uM concentration. For dodecaboranes 50% inhibition was found at 10-times higher concentration.