Neurotoxic Synthesis by Enzymatic Error

The analysis of CNS functions by the use of pharmacological methods has led to the significant result that there are marked differences in each of the regions of the CNS as far as their sensitivity to chemical substances is concerned. Depending on the chemical structure and efficacy of the chemical compounds, gradually increasing doses not only produce therapeutically useful reactions but frequently can also produce reversible or irreversible damage within the same cells. For this reason, the selective vulnerability of certain cerebral regions is of special theoretical and practical significance because the examination of chemically induced neurological disturbances can furnish important information for the recognition of the pathogenesis of neurological diseases.