Effect of Dimeric Netropsin Analogue 15LysbisNt and Acyclovir on the Reproduction of Herpes Simplex Virus Type 1. The Search for Variants of Herpes Virus with Drug Resistance to 15LysbisNt and Acyclovir

One of the problems encountered in the chemo� therapy of viral infections is the formation of mutant virus variants that are resistant to drugs. The probabil� ity of drug resistance development directly depends on the efficiency of viral replication suppression in the course of chemotherapy. If viral replication in the infection focus is inhibited partly, the conditions for selection of resistant variants of the virus existing in the virus population are created [1–3]. The use of binary and ternary combinations of drugs with different mechanism of antiviral action can significantly improve their antiviral activity, thereby ensuring the maximum therapeutic effect even when drugs are used at concentrations lower than the concentration required for monotherapy. This reduces the risk of