Bionic antagonistic vascular endothelial cell and leukocyte adhesion capillary tube, and electrophoresis method and use thereof

2016 
The invention provides a bionic antagonistic vascular endothelial cell and leukocyte adhesion capillary tube, and an electrophoresis method and a use thereof. The method comprises the following steps: cells are cultured on the inner wall of a capillary tube as a stationary phase in an adhesion manner, an antagonistic acceptor-ligand interacting compound is added to a mobile phase, and the capillary tube is used to carry out injection analysis on the cells. One compound with specific cavity can be screened through the method. The brand new capillary electrophoresis method adopting the capillary tube with an adherent cultured cell layer as the stationary phase to carry out injection analysis on the cells can be promoted, and can be applied to rapid screening of anti-adherence drugs under simulated physiological environment conditions by using an intercellular adhesion mechanism.
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