Genomic analysis of advanced malignant soft tissue tumors to suggest effect of genome-wide loss-of-heterozygosity of germline mutations/variants on anti-PD-1 immunotherapy response and survival of the patients.

Katsuhito Takahashi,Yasutomo Miyaji,Hajime Higuchi,Yoshihiro Komohara,Koichi Doi,Hiroko Sano,Shinsuke Aida,Jun Yashima,Hiromasa Yamamoto,Ken Suzawa,Yuko Takahashi,Shinichi Toyooka,Ayumi Saito,Yu Oyama,Hiroyuki Narahara,Junko Yotsumoto,Yasuo Ono,Satoshi Teraoka

Genomic analysis of advanced malignant soft tissue tumors to suggest effect of genome-wide loss-of-heterozygosity of germline mutations/variants on anti-PD-1 immunotherapy response and survival of the patients.

2020

Katsuhito Takahashi
Yasutomo Miyaji
Hajime Higuchi
Yoshihiro Komohara
Koichi Doi
Hiroko Sano
Shinsuke Aida
Jun Yashima
Hiromasa Yamamoto
Ken Suzawa
Yuko Takahashi
Shinichi Toyooka
Ayumi Saito
Yu Oyama
Hiroyuki Narahara
Junko Yotsumoto
Yasuo Ono
Satoshi Teraoka

11531Background: Malignant soft tissue tumor is a rare cancer with few therapeutic options. Although recent genomic characterization of soft tissue sarcoma revealed massive CNA and an excess of pol...

Keywords:

Loss of heterozygosity
Genome
Germline mutation
anti pd 1
Immunotherapy
Pathology
Medicine
Cancer research
Malignant soft tissue tumors

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