Efficacy of sublingual immunotherapy with Dermatophagoides farinae drops in monosensitized and polysensifized patients with allergic rhinitis

Objective To compare the efficacy of sublingual immunotherapy （SLIT） with standardized Dermatophagoides farinae drops in monosensitized and polysensitized patients with allergic rhinitis. Methods The efficacy of SLIT in 69 patients who were sensitized to house dust mites and treated with Dermatophagoides farinae drops for 1.5 -2.0 year with complete clinical data were analyzed retrospectively. These patients had been divided into the monoallergen sensitized group and polyallergen sensitized group according to the results of skin prick tests. The total medication score （TMS） and the total nasal symptoms score （TNSS） were evaluated before and half an year, 1.0 year and 1.5 -2. 0 years after SLIT treatment. Results After SLIT treatment for half an year, the TNSS in the monoallergen sensitized group （2.00[1.00; 3.00]） was significantly lower than that in the polyallergen sensitized group （3.00[2.00;4.00], Z = -2.851, P 0.05）. Half an year, 1.0 year and 1.5 -2.0 years after SLIT treatment, the TMS in both groups reduced significantly, with no significant difference between two groups （Z value was - 0.777, - 0.944, - 0.907, all P > 0.05）. Conclusions SLIT with Dermatophagoides farinae drops is effective in monosensitized and polysensitized patients with allergic rhinitis. And equivalent efficacy could be achieved after 1.5 -2.0 years. Key words: Rhinitis, allergic, perennial; Desensitization, immunologic; Administration, sublingual; Allergens; Treatment outcome