ЭКСПРЕССИЯ ГЕНА HMOX1 В ПЕЧЕНИ КРЫС С ЭКСПЕРИМЕНТАЛЬНЫМ ТЕТРАХЛОРМЕТАНОВЫМ ГЕПАТИТОМ И ЕЕ ИЗМЕНЕНИЕ ПОД ВЛИЯНИЕМ ГЕПАТОПРОТЕКТОРОВ

The article presents the comparative effect of hepatoprotective drugs (heptral, mexidol and methyluracil) on the expression of the HMOX1 gene in toxic liver damage induced by carbon tetrachloride (CCl 4 ). Studies were performed on 70 male white outbred rats. Changes in the expression of the HMOX1 gene were more pronounced 72 hours after administration of CCl  4 . However, under the influence of drugs, changes in expression multiplicity were most marked after 24 hours. The expression of the HMOX1 gene increased in response to all these treatments. The most pronounced response was obtained with the use of oxymethyluracil. Thus, under the toxic action of CCl 4  hepatoprotective drugs enhanced protective and adaptive mechanisms, inducing the activity and expression of the  HMOX1 gene.