Фармакокинетические показатели субстанци НИОХ-14 — нового противооспенного фармакологического вещества

Pharmacokinetics of the parent substance of new anti-smallpox preparation NIOCH-14 (analog of compound ST-246 developed in the United States) was studied in mice after single oral administration at a dose of 50 mg/g body weight (BW) and chronic oral administration for 10 days at doses of 50 and 5 mg/g BW. Concentration of the active metabolite (i.e., ST-246), into which NIOCH-14 is converted in blood serum and homogenates of mouse organs, was determined by liquid chromatography (LC) in combination with tandem mass spectrometry (MS/MS). Based on the pharmacokinetic parameters, the tissue availability of the substance NIOCH-14 was determined for different organs of the mouse, which was 100, 69.6, 20.3, 26.8 and 63.3% for the lungs, liver, spleen, brain and kidneys, respectively.