[Diffusion-weighted magnetic resonance imaging instead of contrast-enhanced imaging for evaluating immediate therapeutic efficacy of high-intensity focused ultrasound ablation of adenomyosis]

Objective To explore the feasibility of diffusion-weighted magnetic resonance imaging (DWI) instead of contrast-enhanced (CE) imaging for evaluation of the immediate therapeutic efficacy of high-intensity focused ultrasound (HIFU) ablation for treatment of adenomyosis. Methods We retrospectively analyzed the data of 29 patients aged 40.5 ± 5.4 years under going HIFU treatment for adenomyosis in our hospital between December, 2017 and July, 2020. The patients received MRI examination both before and within 24 h after the operation. Two observers analyzed the morphology of the ablation area on DWI and classified the lesions into type 1 (spot-like or no obvious signal intensity changes), type 2 (patchy signal intensity changes) and type 3 (ring-like signal intensity changes). The inter- and intra-observer reliability of morphological assessment was assessed using kappa test. The volume of necrotic tissues following the ablation was measured with both DWI and CE imaging, and the consistency of the measurements and the inter- and intra-observer reliability of DWI-based measurements were evaluated using Bland-Altman plot tests. Results The median volume of necrotic tissues was 36.9 cm3 (range 16.4-65.5 cm3) following ablation of the 29 lesions. DWI findings identified 24-25 (82.8%-86.2%) lesions with type 2 or 3 signal changes following the ablation with measurable necrotic tissue volume. On DW images, the Kappa value of intra- and inter-observer reliability for morphological classification of the ablation area reached 0.798 (P=0.000) and 0.933 (P= 0.000), respectively. Bland-Altman plots showed a good consistency of the necrotic volumes measured by CE and at DWI with a strong inter- and intra-observer reliability of DWI-based volume measurements (with only one point outside the range of 95% limits of agreement). The remaining 4 or 5 lesions, which presented with type 1 signal changes following ablation, were all small in size (the largest was only 18.61 cm3) and showed poor therapeutic responses to the ablation. Conclusion DWI-based morphological assessment and necrotic tissue volume measurement can replace CE imaging for assessment of the immediate therapeutic efficacy of HIFU ablation for treatment of adenomyosis.