Novel fluorescent sensors based on zinc(II) bis(dipyrromethenate)s for furosemide detection in organic media

Abstract In this paper, the sensitivity of new fluorescent sensors based on zinc(II) bis(dipyrromethenate)s ([Zn 2 L 2 ]s) to the furosemide presence in organic media is described. It has been shown that the instantaneous spectral response of [Zn 2 L 2 ]s to the furosemide presence is based on the fluorescence quenching effect. Multi-approach analysis (UV–vis and fluorescent titrations, PXRD, FTIR, 1 H NMR, DOSY, and DFT calculations) has shown that the [Zn 2 L 2 ]s fluorescence quenching is associated with the formation of stable [Zn 2 L 2 Fur]s supramolecular systems, capable of photoinduced electron transfer. The furosemide detection limit with using [Zn 2 L 2 ]s was 65–78 μg L −1 . The proposed sensors can be used for the forensic, clinical and sports medicine needs.