Sample Size Determination for Stratified Phase II Cancer Trials with Monotone Order Constraints

Menghao Xu,Ting Ye,Jun-jun Zhao,Menggang Yu

Sample Size Determination for Stratified Phase II Cancer Trials with Monotone Order Constraints

2020

Menghao Xu
Ting Ye
Jun-jun Zhao
Menggang Yu

It is common for clinical trials to include strata of patients with different risks of disease. In cancer trial settings, patients with different prior treatment history, tumor stages, metastatic s...

Keywords:

Monotone polygon
Disease
prior treatment
Phases of clinical research
Cancer
Internal medicine
Mathematics
Likelihood-ratio test
Statistics
Oncology
Clinical trial
Sample size determination

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