Synthesis and preclinical evaluation of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand

Stefano Boschi,Jason T. Lee,Seval Beykan,Roger Slavik,Liu Wei,Claudio Spick,Uta Eberlein,Andreas K. Buck,Filippo Lodi,Gianfranco Cicoria,Johannes Czernin,Michael Lassmann,Stefano Fanti,K. Herrmann

Synthesis and preclinical evaluation of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand

2016

Stefano Boschi
Jason T. Lee
Seval Beykan
Roger Slavik
Liu Wei
Claudio Spick
Uta Eberlein
Andreas K. Buck
Filippo Lodi
Gianfranco Cicoria
Johannes Czernin
Michael Lassmann
Stefano Fanti
K. Herrmann

Purpose The aim of this study was to synthesize and preclinically evaluate an 18F-PSMA positron emission tomography (PET) tracer. Prostate-specific membrane antigen (PSMA) specificity, biodistribution, and dosimetry in healthy and tumor-bearing mice were determined.

Keywords:

Radiology
Urea
Positron emission tomography
Antigen
Glutamate carboxypeptidase II
Whole body counting
Medicine
Biodistribution
Ligand
Radiation exposure
membrane antigen
tissue distribution

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