Adjunctive minocycline in clozapine and amisulpride treated schizophrenia patients with persistent symptoms

Objective Clozapine and amisulpride are two effective antipsychotic and their combination often is used for treatment refractory people with schizophrenia, yet many patients partially respond. Clinical data and the recent literature suggest benefits with minocycline. in our study we adjunct minocycline in five schizophrenic patients and we observed them for a period of 6 months. Methods Our patients received adjunct minocycline (100 mg oral capsule twice daily). Results Using the PANSS, we identified a statistically significant ( P Minocycline was well tolerated and no patient presented side effects. Conclusion Minocycline seems to help significantly schizophrenic patients who do not respond fully to their medication consisted of clozapine and amisulpride. Larger studies are needed to validate these findings.