EFFECTS OF AMINOGLYCOSIDE AND AMINOCYCLITOL ANTIBIOTICS ON BLOOD COAGULATION IN GOATS

Summary Dinev, T., H. Hubenov & L. Lashev, 2006. Effects of aminoglycoside and aminocyclitol antibiotics on blood coagulation in goats. Bulg. J. Vet. Med. , 9, No 4, 293 297. The changes in blood coagulation parameters fibrinogen, thrombin time (TT), prothrombin time (PT) and activated partial thromboplastin time (APTT) were followed out after parenteral application of gentamicin (4 mg/kg), tobramycin (5 mg/kg), amikacin (10 mg/kg), kanamycin (10 mg/kg), apramycin (20 mg/kg) and spectinomycin (20 mg/kg) in goats for 5 days. Increased fibrinogen concentrations and reduced PT values were determined. There was a tendency towards increased APTT values whereas TT was not significantly altered. Although statistically significantly changed vs baseline, all variations were within the physiological ranges. It could be concluded that there were not any significant changes in blood coagulation potential in goats that could possibly induce clinical haemocoagulation troubles.