Preparation and NMR Spectroscopic Studies of the Supramolecular Inclusion Complex of Anabasine and β -Cyclodextrin

Complexation of the alkaloid anabasine by β-cyclodextrin was studied by NMR spectroscopy. The changes of chemical shifts of 1H and 13C nuclei of the substrate and receptor in an inclusion complex were determined. It was found that anabasine reacted with β-cyclodextrin to form a 1:1 stoichiometric supramolecular inclusion complex with the piperidine fragment of the substrate in the receptor inner cavity.