Hypoprothrombinemia-Lupus Anticoagulant Syndrome:A Case Report and Review of Literature

Objective To explore the etiology,diagnosis and treatment of hypoprothrombinemia-lupus anticoagulant syndrome(HLAS).Methods The clinical characteristics and laboratory results of 1 case of HLAS with prolonged bleeding time was analyzed,and the literature was reviewed.Results The clinical manifestation of HLAS varies,from asymptomatic to severe hemorrhage.HLAS was strongly associated with autoimmune diseases in young adults,and glucocorticoids were effective in majority,immunosuppressor or intravenous immunoglobulin(IVIG)was also needed in few cases.Virus associated HLAS was mostly found in children,and can be self-limited,and spontaneous remission within 3 months,few needed glucocoricoids.The main causes of HLAS in adults were tumor,drug related or unknown.Conclusion HLAS is rare.Cases of HLAS should be thoroughly investigated for any known causes and related disorders.