Synthesis method of rivaroxaban

The invention provides a synthesis method of rivaroxaban. The synthesis method comprises the following steps of: (a) reacting a compound shown as a formula (I) with sodium azide to obtain a compound shown as a formula (II), and reacting the compound shown as the formula (II) with acetic anhydride to produce a compound shown as a formula (III); (b) reacting a compound shown as a formula (IV) and a compound shown as a formula (V) to obtain a compound shown as a formula (VI); (c) reacting the compound shown as the formula (VI) with the compound shown as the formula (II) or the compound shown as the formula (III) under the action of an alkali to obtain a compound shown as a formula (VII); (d) reacting the compound shown as the formula (VII) with hydrazine hydrate to obtain a compound shown as a formula (VIII); and (e) reacting the compound shown as the formula (VIII) with a compound shown as a formula (IX) to obtain the compound rivaroxaban shown as a formula (X). The synthesis method has the advantages of fewer reaction steps, mild reaction conditions, simpleness for post-treatment, and suitability for industrial mass production.