Emergence And Management Of Muti-Drug Resistant Pseudomonas Aeruginosa Isolated From Intensive-Care Unit

Objective: To evaluate the antibiotic resistance pattern of Pseudomonas aeruginosa and its prevalence from samplesreceived from Intensive Care Units (adult and neonatal) at PNS Shifa Hospital Karachi.Study Design and Setting: This cross sectional study was carried out at PNS SHIFA hospital.Methodology: Samples including blood, pus, wound swab, sputum and endobronchial washing were received for cultureand sensitivity. Isolates were cultured on blood and MacConkey agar. Antibiotic susceptibility testing was performed byKirby-Bauer and broth microdilution and then analyzed on SPSS version 23.Results were confirmed by VITEK 2.Results: Out of 674 positive clinical specimens 97(14.39%) were positive for Pseudomonas aeruginosa growth. The mostsusceptible antibiotic against Pseudomonas aeruginosa was Polymixin b (94.854%).The least effective antimicrobial wasaztreonam (40.21%sensitive).Conclusion: The prevalence of Pseudomonas aeruginosa from the samples of Intensive Care Units was found to be 14.39%.The most susceptible antibiotic against pseudomonas was Polymixin B. The least effective antimicrobial was aztreonam.